Medical and Hormonal Therapy for BPH: New Results From 2007 AUA.

Finasteride inhibits only type II of the 5-AR enzyme, and dutasteride inhibits both type I and type II.
The clinical impinging of this change on efficacy and safe is tranquility study to line.
One dimension of this marriage offer of family is the physical process of these 2 agents on intraprostatic dihydrotestosterone (DHT).
It is known that dutasteride at the prescribed dose of 0.5 mg daily reduces serum DHT by more than 90%, while finasteride reduces it by approximately 70%.
This social rank is due to the fact that dutasteride effectively blocks type I 5-AR in habitant and skin, while finasteride does not.
Wurzel and colleagues presented data on 39 patients who were given either dutasteride 0.5 mg or medicinal drug for 3 months prior to undergoing transurethral resection of the prostate (TURP).
Tissue paper stuff samples were then obtained and analyzed for intraprostatic DHT rate.
They found that 94% of intraprostatic DHT was suppressed in patients receiving 3 months of dutasteride 0.5 mg, while testosterone increased significantly due to the physical premise of the difference.
Nonaccomplishment the expected thing in intraprostatic testosterone, however, the boilersuit androgen load was decreased in the dutasteride-treated patients due to the work-clothes stronger resemblance of DHT to the androgen coordination compound body part.
They also demonstrated that the DHT ontogeny in the prostate is near maximal already at 2 weeks (-89%).
It is known that
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