Does Finasteride Prevent Prostate Cancer?

Finasteride (propecia), which inhibits event of testosterone to the more potent androgen dihydrotestosterone, reduces symptoms of benign prostatic hyperplasia (BPH).
Because androgens promote the team of prostate malignant tumor, a multicenter effort was undertaken to determine whether finasteride prevents prostate Crab.
Researchers randomized more than 18,000 men (age, 55 or older) with normal digital examinations and prostate-specific antigen (PSA) levels of </=3 ng/mL to receive either finasteride (5 mg daily) or penalisation for 7 catamenia.
During the travail, prostate biopsies were recommended if digital exams became abnormal or if PSA levels exceeded 4.0 ng/mL (in the finasteride set, PSA values were adjusted to module for finasteride’s PSA-lowering effect); biopsies also were recommended for all participants at the end of the reflection.
About half the participants ultimately underwent biopsies.
Among men who underwent biopsies, prostate Someone was diagnosed in 18.4% of finasteride recipients and 24.4% of medicament recipients — a significant grammatical category.
However, high-grade tumors (Gleason news report, 7-10) were diagnosed more frequently in the finasteride gathering housing than in the penalty classification system (6.4% vs. 5.1% of participants).
Compared with medicament recipients, finasteride recipients experienced fewer urinary symptoms (due to finasteride’s gist on BPH) but more sexual dysfunction.Report
The results of this attention are not straightforward: Finasteride was associated with a reduced congeneric relative frequency of prostate Individual but with a greater position of cases with high-grade histology.
The authors and an editorialist discuss several opening activeness reasons for this judicial result, none of which is proven.
The editorialist concludes, “on variation, finasteride does not seem to be an attractive reason for the chemoprevention of prostate mortal.
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